Tumor cell specific and lysosome-targeted delivery of nitric oxide for enhanced photodynamic therapy triggered by 808 nm near-infrared light.

نویسندگان

  • Hui-Jing Xiang
  • Qiao Deng
  • Lu An
  • Min Guo
  • Shi-Ping Yang
  • Jin-Gang Liu
چکیده

A novel cancer cell lysosome-targetable multifunctional NO-delivery nanoplatform (Lyso-Ru-NO@FA@C-TiO2) (1) was developed. It selectively targets folate-receptor overexpressed cancer cells and specifically locates within the lysosome organelle to which NO and reactive oxygen species are simultaneously released upon 808 nm NIR light irradiation. The dual-targeted nanoplatform (1) demonstrated the highest anticancer efficacy compared with nontargeted counterparts under NIR light sensitization.

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عنوان ژورنال:
  • Chemical communications

دوره 52 1  شماره 

صفحات  -

تاریخ انتشار 2016